11 Sudro Hall
Dr. Ang Guo received Ph.D. in physiology and Molecular Cardiology from Shanghai Institute for Biological Sciences, Chinese Academy of Sciences in 2010. Before joining NDSU in 2019 as an assistant professor, he conducted research as research assistant professor and postdoctoral researcher in the University of Iowa. With the funding support from American Heart Association, he laid the groundwork of several mechanisms in cardiac disease development and stress responses. The discoveries are published on top notch journals including Science and PNAS.
Dr. Ang Guo’s research centers on molecular and cellular mechanisms of cardiovascular diseases. Specifically, his lab is focusing on cardiac injury and metabolic stress response mechanisms, including 1). Crosstalk between Excitation-Contraction (E-C) coupling proteins and transcription in heart failure; 2) Exosome mediated cell signaling in cardiac diseases; 3) Crosstalk between metabolomics and epi-transcriptomic in cardiovascular diseases. He is also interested in translating mechanistic insights into novel therapies in cardiovascular disease models. His research uses multidisciplinary approaches including biochemistry, molecular cellular biology, genetics, physiology, and engineering.
Two Research Assistant Opening, Fall 2020
Dr. Guo is looking for highly motivated Ph.D. students. The research/teaching assistantship is available. An earned master degree is preferred. The prospective students will work on the projects of cardiovascular pharmacology and pathophysiology studies, as well as cardiovascular exosome signaling studies. If you are interested in Dr. Guo’s research areas, please send your resume to email@example.com.
Visiting students/scholars, and Undergraduate students’ internship: Please email your CV to firstname.lastname@example.org, if you are interested in joining Dr. Guo's group. Hourly-based financial support is available.
Ph.D.: Physiology and Molecular Cardiology, 09/2003-03/2010
Shanghai Institute of Health Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
B.S.: Biochemical Engineering, 09/1999-06/2003
Nanjing University of Technology, China
Academic and Professional Appointments
Assistant Professor, Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND, 08/2019-present
Funding Sources/Grants Awarded
11/25/2019 - 07/31/2020 NIH 1R15CA195499-01A1 (PI)
10/2019 – 05/2020 NDSU EPSCoR Internal Funding (PI)
07/2016 – 06/2019 American Heart Association (AHA) Scientific Development Grant (SDG) (PI)
07/2017-06/2018 Pilot funding of Hypertension Center, University of Iowa (PI)
01/2013-12/2014 American Heart Association (AHA) Postdoctoral Award Fellowship (PI)
First or equal contribution author publications
1. Ang Guo, Yihui Wang, Biyi Chen, Yunhao Wang, Jinxiang Yuan, Liyang Zhang, Duane Hall, Jennifer Wu, Yun Shi, Qi Zhu, Cheng Chen, William H. Thiel, Xin Zhan, Robert M. Weiss, Fenghuang Zhan, Catherine A. Musselman, Miles Pufall, Weizhong Zhu, Kin Fai Au, Jiang Hong, Mark E. Anderson, Chad E. Grueter, Long-Sheng Song. E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator. Science. 2018 Dec 21; 362(6421). pii: eaan3303.
2. Guo A, Chen R, Wang Y, Huang CK, Chen B, Kutschke W, Hong J, Song LS. Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity. J Mol Cell Cardiol. 2018 Jan 4. pii: S0022-2828(18)30012-9.
3. Guo A, Hall D, Zhang C, Peng T, Miller JD, Kutschke W, Grueter CE, Johnson FL, Lin RZ, Song LS. Molecular determinants of calpain-dependent cleavage of junctophilin-2 protein in cardiomyocytes. Journal of Biological Chemistry. 2015 July 17; 290(29):17946-55.
4. Guo A, Zhang XY, Iyer V.R, Chen B, Zhang C, Kutschke W, Weiss RM, Franzini-Armstrong C & Song LS. Overexpression of junctophilin-2 does not enhance baseline cardiac function but attenuates the development of heart failure following cardiac stress. Proc Natl Acad Sci U S A. 2014 Aug 19; 111(33):12240-5.
5. Guo A and Song LS, AutoTT: Automated Detection and Analysis of T-Tubule Architecture in Cardiomyocytes, Biophysical Journal. 2014 Jun 17; 106(12):2729-36.
6. Chen B, Guo A*, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS. Critical roles of Junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovascular Research. 2013 Oct 1;100(1):54-62 (* co-first author)
7. Guo A, Zhang C, Wei S, Chen B, Song LS. Emerging mechanisms of T-tubule remodeling in heart failure. Cardiovascular Research. 2013 May 1; 98(2):204-15.
8. Guo A, Cala SE and Song LS. Calsequestrin Accumulation in Rough Endoplasmic Reticulum Promotes Perinuclear Ca2+ Release and Myocyte Hypertrophy. Journal of Biological Chemistry. 2012 May 11; 287(20):16670-80.
9. Wei S, Guo A*, Chen B, Kutschke W, Xie YP, Zimmerman K, Weiss RM, Anderson ME, Cheng H, and Song LS. T-tubule remodeling during transition from hypertrophy to heart failure. Circulation Research. 2010 Aug 20; 107(4):520-31. ( * co-first author; cover story)
10. Guo A, Yang HT. Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes. American Journal of Physiology Cell Physiol. 2009 Sep; 297(3):C732-41.
11. Zhang C, Chen B, Wang Y, Guo A, Tang Y, Khataei T, Shi Y, Kutschke WJ, Zimmerman K, Weiss RM, Liu J, Benson CJ, Hong J, Ma J, Song LS. MG53 is dispensable for T-tubule maturation but critical for maintaining T-tubule integrity following cardiac stress. J Mol Cell Cardiol. 2017 Aug 16.
12. Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT. Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo. Circ Res. 2017 Jun 9;120(12):1874-1888.
13. Zhong X, Sun B, Vallmitjana A, Mi T, Guo W, Ni M, Wang R, Guo A, Duff HJ, Gillis AM, Song LS, Hove-Madsen L, Benitez R, Chen SR. Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts. Biochem J. 2016 Nov 1;473(21):3951-3964.
14. Arora R, Aistrup GL, Supple S, Frank C, Singh J, Tai S, Zhao A, Chicos L, Marszalec W, Guo A, Song LS, Wasserstrom JA. Regional distribution of T-tubule density in left and right atria in dogs. Heart Rhythm. 2017 Feb;14(2):273-281.
15. Zhu Y, Zhang C, Chen B, Chen R, Guo A, Hong J, Song LS. Cholesterol is required for maintaining T-tubule integrity and intercellular connections at intercalated discs in cardiomyocytes. J Mol Cell Cardiol. 2016 Aug;97:204-12.
16. C Crocini, C Ferrantini, M Scardigli, R Coppini, L Mazzoni, E Lazzeri, JM Pioner, B Scellini, A Guo, LS Song, P Yan, LM Loew, J Tardiff, C Tesi, F Vanzi, E Cerbai, FS Pavone, L Sacconi, C Poggesi. Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2016 Feb;91:42-51.
17. Chen B, Zhang C, Guo A, Song LS. In situ single photon confocal imaging of cardiomyocyte T-tubule system from Langendorff-perfused hearts. Front Physiol. 2015 May 6;6:134.
18. Ye Y, Sun Z, Guo A, Song LS, Grobe JL, Chen S. Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia. Cell Signal. 2014 Nov;26(11):2514-20.
19. Zhang J, Chen B, Zhong X, Mi T, Guo A, Zhou Q, Tan Z, Wu G, Chen AW, Fill M, Song LS, Chen SR. The Cardiac Ryanodine Receptor Luminal Ca2+ Sensor Governs Ca2+ Waves, Ventricular Tachyarrhythmias, and Cardiac Hypertrophy in Calsequestrin Null Mice. Biochem J. 2014 Jul 1;461(1):99-106.
20. Chen W, Wang R, Chen B, Kong H, Zhou Q, Xie C, Tian X, Guo A, Bai Y, Jones PP, O’Mara M, Zhang L, Bolstad J, Semeniuk L, Cheng H, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS and Chen SRW. A store Ca2+ sensing gate controls Ca2+ waves and Ca2+ triggered arrhythmias. Nature Medicine. 2014 Feb; 20(2):184-92.
21. Zhang C, Chen B, Guo A, Zhu Y, Miller J, Kutschke W, Zimmerman K, Weiss RM, Wehrens XHT, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte T-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014, 129(17):1742-50
22. Bai Y, Jones PP, Guo J, Zhong X, Clark RB, Zhou Q, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Semeniuk L, Guo A, Song LS, Duff HJ, Chen SR. Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice. Circulation Research. 2013 Aug 16;113(5):517-26.
23. Chen B, Li Y, Jiang S, Xie YP, Guo A, Kutschke J, Zimmerman K, Weiss RM, Miller F, Anderson ME, Song LS. b-adrenergic receptor blockers ameliorate myocyte T-tubule remodeling following myocardial infarction. FASEB J. 2012 Jun;26(6):2531-7.
24. Xie YP, Chen B, Sanders P, Guo A, Li Y, Zimmerman K, Wang LC, Weiss RM, Grumbach IM, Anderson ME, Song LS. Sildenafil Prevents and Reverses Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Right Ventricle Failure Induced by Pulmonary Artery Hypertension. Hypertension. 2012, 59: 355-362
25. Chen B, Guo A, Wei S, Xie YP, Chen SRW, Anderson ME, Song LS. In Situ Confocal Imaging of Ca2+ handling and Ex Vivo ECG in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia: Mutated ryanodine receptors are not leaky at rest, but exhibit high Ca2+ release variability under stress. Circulation Arrhythmia and Electrophysiology. 2012 Jun 21.
26. Song LS, Guo A, Lin RZ. MicroRNA: a toolkit fine-tuning the dyadic "fuzzy space"? Circulation Research. 2012 Sep 14;111(7):816-8.
27. Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nature Medicine. 2011 Jul 10;17(8):1003-9.
28. Li J, Zhang H, Zhu WZ, Yu Z, Guo A, Yang HT, Zhou ZN. Preservation of the pHi during ischemia via PKC by intermittent hypoxia. Biochem Biophys Res Commun. 2007 Aug 3; 359(3):841.
29. Wang Y, Chen B, Huang CK, Guo A, Wu J, Zhang X, Chen R, Chen C, Kutschke W, Weiss RM, Boudreau RL, Margulies KB, Hong J, Song LS. Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models. JACC Basic Transl Sci. 2018 Aug 28;3(4):503-517.
Independently developed AutoTT, which is an image analysis software used for processing and analyzing structure of sarcomere and T-tubules in myocytes. More than 30 labs all over the world requested and used this software.
Independently developed CaTeasy, which is a software used for analyzing Ca2+ signals imaged by confocal microscopy. This software is used routinely in my lab.