203 Sudro Hall
Office Phone: 701.231.6371
Lab Phone: 701.231.8106
Chemotherapeutic/Infectious Disease Pharmacodynamics (PSCI 412) and Pharmacogenomics (PSCI 417) for Pharm D students.
1999-2003, Ph.D., Biochemistry, University of Madras, Chennai, India
1997-1999, M.Sc., Biochemistry, Bharathiar University, Coimbatore, India
1994-1997, B.Sc., Biochemistry, University of Madras, Chennai, India
The research laboratory of Dr. Venkatachalem, studies human lung diseases such as asthma, chronic obstructive pulmonary disease, lymphangioleiomyomatosis (LAM) disease and pulmonary hypertension. With reference to asthma, incidence and severity is higher in both pre-menopausal women and in aging men, suggesting a role for female sex steroids (estrogen) in modulating this disease. However, it is not clear whether and how estrogens impact the airway. Furthermore, women may be biologically more susceptible to cigarette smoke exposure than men when it comes to incidence of and complications from smoking-related airway diseases. Our studies using human airway smooth muscles from both male and female asthmatics vs. non-asthmatics, smokers vs. Non-smokers along with animal studies where we control sex steroids levels or their signaling will substantially enhance our understanding of how and why estrogens influence the asthmatic airway. In addition, LAM disease almost exclusively affects women. The mechanistic basis of gender specific LAM progression is still not well understood. We believe our focused studies will yield novel mechanistic information on LAM pathogenesis. Relevant sex storied signaling, studies regarding breast cancer and nanomedicine based drug delivery towards clinical translational research also of interest of the lab with collaborative fashion.
Academic and Professional Appointments
Department of Pharmaceutical Sciences,
North Dakota State University, Fargo, ND, USA
2018- Present Co-Director
Pilot project core Dakota cancer collaborative on translational activity (DaCCoTA) North Dakota
2017-present, WOC Scientist
Veterans Affairs Hospital, Fargo
2016-present, Adjunct Assistant Professor of Physiology
Mayo Clinic, Rochester, MN, USA
2016-present, Adjunct Faculty
JSS University, Karnataka, India
2016-2020, Assistant Professor
Department of Pharmaceutical Sciences, North Dakota State University, Fargo
2016, Associate Consultant
Mayo Clinic, Rochester, MN, USA
2012-2016, Assistant Professor of Physiology
Mayo Clinic, Rochester, MN, USA
2007, Research Associate
Departments of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA
2003-2006, Postdoctoral Research Associate
Heart Failure Research Group, Dept. of Physiology and Pharmacology, University of Western Ontario, London, Canada
2020, Dean’s Award for excellence in Research, College of Health Professions
2018, Experimental Biology and Medicine (EBM) outstanding Reviewer Award
2018, American Physiological Society Research Host for USRF program
2017, Impact Fund Award, NDSU Foundation and Alumni Association at Fargo, ND, USA
2016, Rising stars of Research Award in ATS Science and Innovation Center at American Thoracic Society, San Francisco, USA
2014, First place on the Best poster competition in 13th Scientific Symposium of the Flight Attendant Medical Research Institute (FAMRI), Miami, FL, USA
2013, Dr. Duane K Rorie award for excellence in laboratory based research by the Department of Anaesthesiology, Mayo Clinic, MN, USA
2013, First place on the Best poster competition in 12th Scientific Symposium of the Flight Attendant Medical Research Institute (FAMRI), Miami, FL, USA
2013-2016, Young Clinical Scientist Award – Faculty Flight Attendants Medical Research Institute (FAMRI), USA
2011-2012, Young Clinical Scientist Award – Fellow Flight Attendants Medical Research Institute (FAMRI), USA
2009, Dr. Duane K Rorie award for excellence in laboratory based research by the Department of Anaesthesiology, Mayo Clinic, MN, USA
2003-2006, Postdoctoral Research Fellowship - Heart and Stroke Foundation of Ontario program grant in Heart Failure, Canada.
2002-2003, Awarded Senior Research Fellowship - Council of Scientific and Industrial
Professional Society Memberships
2018-present, American Society of Pharmacology and Experimental Therapeutics (ASPET) - Member
2018-present, Society for Experimental Biology and Medicine
2015-present, American Physiological Society - Member
2011-present, American Thoracic Society – Member
2009-2011, North American Vascular Biology Organization –Training Member
2007-2012, American Physiological Society – Member
Journal Editorial Boards:
Frontiers in Physiology – Review Editor
JSM Biochemistry & Molecular Biology- Associate Editor
International Journal of Pulmonology and Clinical Research - Editorial Board
Mediators of Inflammation- Served as an invited Lead Guest Editor
Ad hoc Reviewer:
Frontiers in Physiology, Translational Research, Molecular and Cellular Endocrinology, Experimental Lung Research, Journal of Cellular and Molecular Medicine, American Journal of Physiology Lung Cellular and Molecular Physiology, Journal of Liquid Chromatography & Related Technologies, Biomedical Research International, Life Sciences, Cellular Physiology and Biochemistry, American Journal of Physiology Heart and Circulatory Physiology, Archives of Medical Science, Molecular and Cellular Biochemistry, Molecular Biology International, Lung, Trials in Vaccinology, Gene, American Journal of Physiology- Endocrine, Scientific Reports, Chinese Journal of Physiology, Journal of Molecular Cell Biology, Clinical Sciences, Respiratory Research, BMC Physiology, Experimental Biology and Medicine, Archives of Biochemistry and Biophysics, Journal of Cellular Physiology, FASEB BioAdvances and Frontiers in Pharmacology, Archives of Microbiology, International Journal of Molecular Sciences, Cell and Tissue Research
Lizhi P, Harshit S, Hongzhi W, Dan S, Steven YQ, Sathish V. EpCAM targeted 3WJ RNA nanoparticle harboring delta-5-desaturase siRNA inhibited lung tumor formation via DGLA peroxidation. Mol. Ther. Nucleic Acids. 2020 (In press).
Kalidhindi RSR, Ambhore NS, Bhallamudi S, Loganathan J, Sathish V. 2020. Role of Estrogen Receptors α and β in a Murine Model of Asthma: Exacerbated Airway Hyperresponsiveness and Remodeling in ERβ Knockout Mice. Frontiers in Pharmacology 10: 1499.
Bhallamudi S, Connell J, Pabelick CM, Prakash YS, Sathish V. 2020. Estrogen Receptors Differentially Regulates Intracellular Calcium Handling in Human Non-asthmatic and Asthmatic Airway Smooth Muscle Cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 318(1):L112-L124.
Ambhore NS, Kalidhindi RS, Pabelick CM, Hawse JR, Prakash YS, Sathish V. 2019. Differential estrogen-receptor activation regulates extracellular matrix deposition in human airway smooth muscle remodeling via NF-κB pathway. The FASEB Journal 33(12):13935-13950.
Kalidhindi RSR, Katragadda R, Beauchamp KL, Pabelick CM, Prakash YS, Sathish V. Androgen receptor-mediated regulation of intracellular calcium in human airway smooth muscle cells. Cell Physiol Biochem. 2019; 53(1):215-228.
Loganathan J, Pandey R, Ambhore NS, Borowicz P, Sathish V. Laser-capture microdissection of murine lung for differential cellular RNA analysis. Cell Tissue Res. 2019; 376(3):425-432
Kolumam Parameswaran P, Dai D, Ding YH, Urban MW, Manlove L, Sathish V, Cebral JR, Kallmes DF, Kadirvel R. Downstream vascular changes after flow-diverting device deployment in a rabbit model. J Neurointerv Surg. 2019; 11(5):523-527
Ambhore NS, Katragadda R, Raju KRS, Thompson MA, Pabelick CM, Prakash YS, Sathish V. Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation. Mol Cell Endocrinol. 2018: 476:37-47
Habib A, Sathish V, Mallik S, Khoda B. 3D Printability of Alginate-Carboxymethyl Cellulose Hydrogel. Materials (Basel). 2018: 20;11 (3).
Aravamudan B, Goorhouse KJ, Unnikrishnan G, Thompson MA, Pabelick CM, Hawse JR, Prakash YS, Sathish V. Differential Expression of Estrogen Receptor Variants in Response to Inflammation Signals in Human Airway Smooth Muscle. J Cell Physiol. 2017; 232(7):1754-60.
*Freeman MR, *Sathish V, Manlove L, Wang S, Britt RD, Thompson MA, Pabelick CM, Prakash YS. Brain Derived neurotropic factor and Airway fibrosis in asthma. American journal of physiology Lung cellular and molecular physiology. 2017;313: L360-7017
Wang S, Sathish V, Freeman MR, Thompson MA, Pabelick CM, Prakash YS. Secreted BDNF asthma severity. Am J Respir Cell Mol Biol. 2016; 54(2):297.
Wang S, Freeman MR, Sathish V, Thompson MA, Pabelick CM, Prakash YS. Sex Steroids Influence Brain-Derived Neurotropic Factor Secretion from Human Airway Smooth Muscle Cells. J Cell Physiol. 2016; 231: 1586-92
*Yarova PL, *Stewart A, *Sathish V, *Britt Jr RD, Thompson MA, Lowe APP, et al. Calcium-sensing receptor antagonists abrogate airways hyperresponsiveness and inflammation in allergic asthma. Science Translational Medicine. 2015; 7 (284): 284ra60
Hartman WT, Helan M, Smelter DF, Sathish V, et al. Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle. PloS one. 2015; 10 (7): e0129489.
Sathish V, Freeman MR, Long E, Thompson MA, Pabelick CM, Prakash YS. Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle. Cell Physiol Biochem. 2015;36(3):1101-15
Wylam ME, Sathish V, VanOosten SK, Freeman M, Burkholder D, Thompson MA, et al. Mechanisms of Cigarette Smoke Effects on Human Airway Smooth Muscle. PloS one. 2015;10 (6): e0128778.
Marudamuthu AS, Shetty SK, Bhandary YP, Karandashova S, Thompson M, Sathish V, et al. Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrosis lungs. J Biol Chem. 2015;290(15):9428-41. PMCID: 4392249.
Marudamuthu AS, Bhandary YP, Shetty SK, Fu J, Sathish V, Prakash Y, et al. Role of the Urokinase-Fibrinolytic System in Epithelial-Mesenchymal Transition during Lung Injury. Am J Pathol. 2015;185(1):55-68. PMCID: 4278237.
Sathish V, Thompson MA, Sinha S, Sieck GC, Prakash YS, Pabelick CM. Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle. Biochim Biophys Acta. 2014;1843(2):346-51.
Vohra PK, Thompson MA, Sathish V, Kiel A, Jerde C, Pabelick CM, et al. TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle. Biochim Biophys Acta. 2013;1833(12):2953-60. PMCID: 3835538.
Sathish V, Vanoosten SK, Miller BS, Aravamudan B, Thompson MA, Pabelick CM, et al. Brain-derived neurotrophic factor in cigarette smoke-induced airway hyperreactivity. Am J Respir Cell Mol Biol. 2013;48(4):431-8. PMCID: 3653604
Townsend EA, Sathish V, Thompson MA, Pabelick CM, Prakash YS. Estrogen effects on human airway smooth muscle involve cAMP and protein kinase A. American journal of physiology Lung cellular and molecular physiology. 2012;303 (10): L923-8. PMCID: 3517674.
Sathish V, Abcejo AJ, Thompson MA, Sieck GC, Prakash YS, Pabelick CM. Caveolin-1 regulation of store-operated Ca2+ influx in human airway smooth muscle. The European Respiratory Journal: 2012;40 (2): 470-8.
Hartman WR, Smelter DF, Sathish V, Karass M, Kim S, Aravamudan B, et al. Oxygen dose responsiveness of human fetal airway smooth muscle cells. American journal of physiology Lung cellular and molecular physiology. 2012;303 (8): L711-9. PMCID: 3469631.
Grim KJ, Abcejo AJ, Barnes A, Sathish V, Smelter DF, Ford GC, et al. Caveolae and propofol effects on airway smooth muscle. British journal of anesthesia. 2012;109(3):444-53. PMCID: 3415286.
Abcejo AJ, Sathish V, Smelter DF, Aravamudan B, Thompson MA, Hartman WR, et al. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PloS one. 2012;7 (8): e44343. PMCID: 3430656.
Sathish V, Yang B, Meuchel LW, VanOosten SK, Ryu AJ, Thompson MA, et al. Caveolin-1 and force regulation in porcine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2011;300 (6): L920-9.
Sathish V, Delmotte PF, Thompson MA, Pabelick CM, Sieck GC, Prakash YS. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. PloS one. 2011;6 (8): e23662.
Sathish V, Abcejo AJ, Vanoosten SK, Thompson MA, Prakash YS, Pabelick CM. Caveolin-1 in cytokine-induced enhancement of intracellular Ca2+ in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2011;301 (4): L607-14.
*Smelter DF, *Sathish V, Thompson MA, Pabelick CM, Vassallo R, Prakash YS. Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscle. J Immunol. 2010;185(5):3035-40.
Sathish V, Thompson MA, Bailey JP, Pabelick CM, Prakash YS, Sieck GC. Effect of proinflammatory cytokines on regulation of sarcoplasmic reticulum Ca2+ reuptake in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2009;297 (1): L26-34.
Prakash YS, Sathish V, Thompson MA, Pabelick CM, Sieck GC. Asthma and Sarcoplasmic Reticulum Ca2+ Reuptake in Airway Smooth Muscle. Am J Physiol Lung Cell Mol Physiol. 2009; 297 (4): L794
Sathish V, Leblebici F, Kip SN, Thompson MA, Pabelick CM, Prakash YS, et al. Regulation of sarcoplasmic reticulum Ca2+ reuptake in porcine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2008;294 (4): L787-96.
Senthilkumar S EK, Sathish V, Yogeeta S, Devaki T. Modulation of the tissue defense system by squalene in cyclophosphamide induced toxicity in rats. Archives of Medical Science. 2007;2(2):94-100.
Gnanapragasam A, Yogeeta S, Subhashini R, Ebenezar KK, Sathish V, Devaki T. Adriamycin induced myocardial failure in rats: protective role of Centella asiatica. Mol Cell Biochem. 2007;294(1-2):55-63.
Geoghegan-Morphet N, Burger D, Lu X, Sathish V, Peng T, Sims SM, et al. Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes. Cardiovasc Res. 2007;75(2):408-16.
Sathish V, Xu A, Karmazyn M, Sims SM, Narayanan N. Mechanistic basis of differences in Ca2+ -handling properties of sarcoplasmic reticulum in right and left ventricles of normal rat myocardium. Am J Physiol Heart Circ Physiol. 2006;291 (1): H88-96.
Book chapters / Invited Review
Prakash YS, Sathish V, Townsend E. Sex Steroid Signaling in the Airway. In: Wang Y-X, editor. Calcium Signaling in Airway Smooth Muscle Cells: Springer International Publishing; 2014. p. 321-32.
Sathish V, Martin YN, Prakash YS. Sex steroid signaling: implications for lung diseases. Pharmacol Ther. 2015; 150:94-108
Sathish V and Prakash YS. Sex Differences in Pulmonary Anatomy and Physiology: Implications for Health and Disease. In: Neigh GN and Mitzefelt MM, editors. Sex Differences in Physiology: Academic Press; 2016: p. 89-103.
Kalidhindi RS, Ambhore NS, Sathish V. Morphological, bio-chemical and molecular analysis of broncho alveolar lavage fluid from murine lungs. “Animal models of Allergic Diseases” Methods in Molecular Biology 2020 (In press)
Borkar NA and Sathish V. Sex steroids and their influence in lung disease across the lifespan. In: Silveyra P and Xenia T, editors. Sex-Based Differences in Lung Physiology, published by Springer 2020 (In press).
Ambhore NS, Kalidhindi RS, Sathish V. sex steroid signaling in lung diseases and inflammation. In: Wang Y-X, editor. Lung Inflammation in Health and Disease: Springer International Publishing; 2020. (In press)